Capillary electrophoresis

Capillary electrophoresis

Capillary electrophoresis

Capillary electrophoresis trials (CE) began as early as 1800’s. Experimentations started with the use of U tube glasses and trials of both free and gel solutions (Li, 1992). Arnes Tiselius in 1930’s first conducted an experiment that demonstrated the capability of electrophoresis that revealed the proteins separation in free solutions (Camilleri, 1997). His work had was ignored until Hjerten in 1960’s introduced the use of capillaries.

Conversely, their establishments were not widely acknowledged until Lukacs and Jorgenson published papers presenting the capability of capillary electrophoresis to conduct separations that appeared impossible. Using a capillary in electrophoresis had solved some widespread problems in conventional electrophoresis (Petersen, John and Amin, 2001).

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For the future of modified medicine, especially for multifactorial diseases, human genome will be sequenced using a “sample in / sequence out” technique. Of late, capillary electrophoresis has found a fresh application in the analysis of increased activities of CE-MS techniques and complex carbohydrates in the biopharmaceutical and biotechnology industry.

The high power of capillary electrophoresis and its hyphenation with MS provides a good option to presently used separation methods for the study of this significant class of biopolymers with the anticipation to decipher the glycome.

References
Altria, Kevin D., Capillary Electrophoresis (1995). Guidebook : Principles, Operation and Applications. New York: Humana

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